Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury

Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury

Acute kidney injury (AKI) leads to unacceptably high mortality due to difficulties in timely intervention and less efficient renal delivery of therapeutic drugs. Here, a series of polyvinylpyrrolidone (PVP)-curcumin nanoparticles (PCurNP) are designed to meet the renal excretion threshold (∼45 kDa),...

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Bibliographic Details
Main Authors: Hao Wei, Dawei Jiang, Bo Yu, Dalong Ni, Mengting Li, Yin Long, Paul A. Ellison, Cerise M. Siamof, Liang Cheng, Todd E. Barnhart, Hyung-Jun Im, Faquan Yu, Xiaoli Lan, Xiaohua Zhu, Qianjun He, Weibo Cai
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-01-01
Series:Bioactive Materials
Subjects:
Nanomedicine
Acute kidney injury
Kidney targeting
Positron emission tomography (PET) imaging
Zirconium-89 (89Zr)
Nuclear medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X2200175X

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http://www.sciencedirect.com/science/article/pii/S2452199X2200175X

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