Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury
Acute kidney injury (AKI) leads to unacceptably high mortality due to difficulties in timely intervention and less efficient renal delivery of therapeutic drugs. Here, a series of polyvinylpyrrolidone (PVP)-curcumin nanoparticles (PCurNP) are designed to meet the renal excretion threshold (∼45 kDa),...
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KeAi Communications Co., Ltd.
2023-01-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X2200175X |
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| author | Hao Wei Dawei Jiang Bo Yu Dalong Ni Mengting Li Yin Long Paul A. Ellison Cerise M. Siamof Liang Cheng Todd E. Barnhart Hyung-Jun Im Faquan Yu Xiaoli Lan Xiaohua Zhu Qianjun He Weibo Cai |
| author_facet | Hao Wei Dawei Jiang Bo Yu Dalong Ni Mengting Li Yin Long Paul A. Ellison Cerise M. Siamof Liang Cheng Todd E. Barnhart Hyung-Jun Im Faquan Yu Xiaoli Lan Xiaohua Zhu Qianjun He Weibo Cai |
| author_sort | Hao Wei |
| collection | DOAJ |
| description | Acute kidney injury (AKI) leads to unacceptably high mortality due to difficulties in timely intervention and less efficient renal delivery of therapeutic drugs. Here, a series of polyvinylpyrrolidone (PVP)-curcumin nanoparticles (PCurNP) are designed to meet the renal excretion threshold (∼45 kDa), presenting a controllable delivery nanosystem for kidney targeting. Renal accumulation of the relatively small nanoparticles, 89Zr-PCurNP M10 with the diameter between 5 and 8 nm, is found to be 1.7 times and 1.8 times higher than the accumulation of 89Zr-PCurNP M29 (20–50 nm) and M40 (20–50 nm) as revealed by PET imaging. Furthermore, serum creatinine analysis, kidney tissues histology, and tubular injury scores revealed that PCurNP M10 efficiently treated cisplatin-induced AKI. Herein, PCurNP offers a novel and simple strategy for precise PET image-guided drug delivery of renal protective materials. |
| first_indexed | 2024-04-11T20:32:42Z |
| format | Article |
| id | doaj.art-b926ed7951d44e17b8137e34c266f6d8 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:42:28Z |
| publishDate | 2023-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-b926ed7951d44e17b8137e34c266f6d82024-04-16T15:30:39ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-01-0119282291Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injuryHao Wei0Dawei Jiang1Bo Yu2Dalong Ni3Mengting Li4Yin Long5Paul A. Ellison6Cerise M. Siamof7Liang Cheng8Todd E. Barnhart9Hyung-Jun Im10Faquan Yu11Xiaoli Lan12Xiaohua Zhu13Qianjun He14Weibo Cai15Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USADepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USANational-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen, 518060, China; Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USA; Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430073, ChinaDepartments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USADepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USADepartments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USADepartments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USADepartments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USAInstitute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, ChinaDepartments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USADepartments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USAKey Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430073, ChinaDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Corresponding author.Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China; Corresponding author.National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen, 518060, China; Corresponding author.Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USA; University of Wisconsin Carbone Cancer Center, University of Wisconsin–Madison, Madison, WI, 53705, USA; Corresponding authors. Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, WI, 53705, USA.Acute kidney injury (AKI) leads to unacceptably high mortality due to difficulties in timely intervention and less efficient renal delivery of therapeutic drugs. Here, a series of polyvinylpyrrolidone (PVP)-curcumin nanoparticles (PCurNP) are designed to meet the renal excretion threshold (∼45 kDa), presenting a controllable delivery nanosystem for kidney targeting. Renal accumulation of the relatively small nanoparticles, 89Zr-PCurNP M10 with the diameter between 5 and 8 nm, is found to be 1.7 times and 1.8 times higher than the accumulation of 89Zr-PCurNP M29 (20–50 nm) and M40 (20–50 nm) as revealed by PET imaging. Furthermore, serum creatinine analysis, kidney tissues histology, and tubular injury scores revealed that PCurNP M10 efficiently treated cisplatin-induced AKI. Herein, PCurNP offers a novel and simple strategy for precise PET image-guided drug delivery of renal protective materials.http://www.sciencedirect.com/science/article/pii/S2452199X2200175XNanomedicineAcute kidney injuryKidney targetingPositron emission tomography (PET) imagingZirconium-89 (89Zr)Nuclear medicine |
| spellingShingle | Hao Wei Dawei Jiang Bo Yu Dalong Ni Mengting Li Yin Long Paul A. Ellison Cerise M. Siamof Liang Cheng Todd E. Barnhart Hyung-Jun Im Faquan Yu Xiaoli Lan Xiaohua Zhu Qianjun He Weibo Cai Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury Bioactive Materials Nanomedicine Acute kidney injury Kidney targeting Positron emission tomography (PET) imaging Zirconium-89 (89Zr) Nuclear medicine |
| title | Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury |
| title_full | Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury |
| title_fullStr | Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury |
| title_full_unstemmed | Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury |
| title_short | Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury |
| title_sort | nanostructured polyvinylpyrrolidone curcumin conjugates allowed for kidney targeted treatment of cisplatin induced acute kidney injury |
| topic | Nanomedicine Acute kidney injury Kidney targeting Positron emission tomography (PET) imaging Zirconium-89 (89Zr) Nuclear medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X2200175X |
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