Methods for Establishing a Renal Cell Carcinoma Tumor Spheroid Model With Immune Infiltration for Immunotherapeutic Studies

Methods for Establishing a Renal Cell Carcinoma Tumor Spheroid Model With Immune Infiltration for Immunotherapeutic Studies

Tumor spheroids play an increasingly important role in cancer research. Their ability to recapitulate crucial features of tumor biology that are lost in the classically used 2D models along with their relative simplicity and handiness have made them the most studied 3D tumor model. Their application...

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Bibliographic Details
Main Authors: Leonard Lugand, Guillaume Mestrallet, Rebecca Laboureur, Clement Dumont, Fatiha Bouhidel, Malika Djouadou, Alexandra Masson-Lecomte, Francois Desgrandchamps, Stephane Culine, Edgardo D. Carosella, Nathalie Rouas-Freiss, Joel LeMaoult
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
spheroid
renal cell carcinoma
immune checkpoint inhibitors
standardization
PD-1
heterogeneity
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.898732/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.898732/full

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