DMRscaler: a scale-aware method to identify regions of differential DNA methylation spanning basepair to multi-megabase features

DMRscaler: a scale-aware method to identify regions of differential DNA methylation spanning basepair to multi-megabase features

Abstract Background Pathogenic mutations in genes that control chromatin function have been implicated in rare genetic syndromes. These chromatin modifiers exhibit extraordinary diversity in the scale of the epigenetic changes they affect, from single basepair modifications by DNMT1 to whole genome...

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Bibliographic Details
Main Authors: Leroy Bondhus, Angela Wei, Valerie A. Arboleda
Format: Article
Language:English
Published: BMC 2022-09-01
Series:BMC Bioinformatics
Subjects:
Rare disease
Epigenome
Scale, DNA methylation
Chromatin
Arboleda-Tham syndrome
Sotos syndrome
Online Access:https://doi.org/10.1186/s12859-022-04899-1

Internet

https://doi.org/10.1186/s12859-022-04899-1

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