Quinonoid dihydropteridine reductase, a tetrahydrobiopterin-recycling enzyme, contributes to 5-hydroxytryptamine-associated platelet aggregation in mice

Quinonoid dihydropteridine reductase, a tetrahydrobiopterin-recycling enzyme, contributes to 5-hydroxytryptamine-associated platelet aggregation in mice

Quinonoid dihydropteridine reductase (QDPR) regenerates tetrahydrobiopterin (BH4), which is an essential cofactor for catecholamine and serotonin (5-hydroxytryptamine, 5-HT) biosynthesis. Serotonin is known as an important platelet agonist, but its role under BH4-synthesizing or recycling enzymes de...

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Bibliographic Details
Main Authors: Yui Suganuma, Chiho Sumi-Ichinose, Taiki Kano, Kazuhisa Ikemoto, Taei Matsui, Hiroshi Ichinose, Kazunao Kondo
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Journal of Pharmacological Sciences
Subjects:
Quinonoid dihydropteridine reductase
Tetrahydrobiopterin
Platelet aggregation
Serotonin
Secondary aggregation
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861322000664

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http://www.sciencedirect.com/science/article/pii/S1347861322000664

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