Pterostilbene Increases LDL Metabolism in HL-1 Cardiomyocytes by Modulating the PCSK9/HNF1α/SREBP2/LDLR Signaling Cascade, Upregulating Epigenetic hsa-miR-335 and hsa-miR-6825, and LDL Receptor Expression

Pterostilbene Increases LDL Metabolism in HL-1 Cardiomyocytes by Modulating the PCSK9/HNF1α/SREBP2/LDLR Signaling Cascade, Upregulating Epigenetic hsa-miR-335 and hsa-miR-6825, and LDL Receptor Expression

Proprotein convertase subtilisin/kexin type 9 (PCSK9) can promote the degradation of low-density lipoprotein (LDL) receptor (LDLR), leading to hypercholesterolemia and myocardial dysfunction. The intracellular regulatory mechanism by which the natural polyphenol pterostilbene modulates the PCSK9/LDL...

Celý popis

Podrobná bibliografie
Hlavní autoři: Yen-Kuang Lin, Chi-Tai Yeh, Kuang-Tai Kuo, Vijesh Kumar Yadav, Iat-Hang Fong, Nicholas G. Kounis, Patrick Hu, Ming-Yow Hung
Médium: Článek
Jazyk:English
Vydáno: MDPI AG 2021-08-01
Edice:Antioxidants
Témata:
pterostilbene
LDLR
PCSK9
SREBP2
HNF1α
hyperlipidemia
On-line přístup:https://www.mdpi.com/2076-3921/10/8/1280

Internet

https://www.mdpi.com/2076-3921/10/8/1280

Podobné jednotky