Localized accumulation of Xist RNA in X chromosome inactivation

The non-coding RNA Xist regulates the process of X chromosome inactivation, in which one of the two X chromosomes present in cells of early female mammalian embryos is selectively and coordinately shut down. Remarkably Xist RNA functions in cis, affecting only the chromosome from which it is transcr...

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Bibliographic Details
Main Author: Neil Brockdorff
Format: Article
Language:English
Published: The Royal Society 2019-12-01
Series:Open Biology
Subjects:
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.190213