Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans

Understanding how an organism's nervous system transforms sensory input into behavioral outputs requires recording and manipulating its neural activity during unrestrained behavior. Here we present an instrument to simultaneously monitor and manipulate neural activity while observing behavior i...

Full description

Bibliographic Details
Main Authors: Frederick B Shipley, Christopher M Clark, Mark J Alkema, Andrew Michael Leifer
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Neural Circuits
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncir.2014.00028/full