GABAB Receptor Agonist R-Baclofen Reverses Altered Auditory Reactivity and Filtering in the Cntnap2 Knock-Out Rat

GABAB Receptor Agonist R-Baclofen Reverses Altered Auditory Reactivity and Filtering in the Cntnap2 Knock-Out Rat

Altered sensory information processing, and auditory processing, in particular, is a common impairment in individuals with autism spectrum disorder (ASD). One prominent hypothesis for the etiology of ASD is an imbalance between neuronal excitation and inhibition. The selective GABAB receptor agonist...

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Bibliographic Details
Main Authors: Dorit Möhrle, Wenxuan Wang, Shawn N. Whitehead, Susanne Schmid
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Integrative Neuroscience
Subjects:
autism spectrum disorders
sensory processing
startle
GABA
R-Baclofen
CNTNAP2
Online Access:https://www.frontiersin.org/articles/10.3389/fnint.2021.710593/full

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https://www.frontiersin.org/articles/10.3389/fnint.2021.710593/full

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