HPLC determination of an anti-epileptic drug: zonisamide(抗癫痫药唑尼沙胺的HPLC质量分数测定法)
采用ZORBAX Eclipse XDB-C18色谱柱（4.6 mm× 150 mm，5 µm），以甲醇-水（80 ： 20）作为流动相，流速为0.3 mL/min；紫外检测波长为240 nm.用卡马西平作为内标测定唑尼沙胺(zonisamide，ZNS)原药的质量分数.此方法对唑尼沙胺的线性范围是5~100 µg/mL，相关系数r=0.999 8；最低检测限为0.9 ng；平均回收率为98.52%~102.49%, RSD是0.28%~1.21%.结果表明用反相HPLC测定唑尼沙胺原药质量分数操作简便，结果准确....
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| Format: | Article |
| Language: | zho |
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Zhejiang University Press
2007-05-01
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| Series: | Zhejiang Daxue xuebao. Lixue ban |
| Subjects: | |
| Online Access: | https://doi.org/zjup/1008-9497.2007.34.3.324-325 |