Antidepressants stimulate hippocampal neurogenesis by inhibiting p21 expression in the subgranular zone of the hipppocampus.

Antidepressants stimulate hippocampal neurogenesis by inhibiting p21 expression in the subgranular zone of the hipppocampus.

The relationships among hippocampal neurogenesis, depression and the mechanism of action of antidepressant drugs have generated a considerable amount of controversy. The cyclin-dependent kinase (Cdk) inhibitor p21(Cip1) (p21) plays a crucial role in restraining cellular proliferation and maintaining...

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Bibliographic Details
Main Authors: Robert N Pechnick, Svetlana Zonis, Kolja Wawrowsky, Rosemarie Cosgayon, Catherine Farrokhi, Liliana Lacayo, Vera Chesnokova
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3208633?pdf=render

Internet

http://europepmc.org/articles/PMC3208633?pdf=render

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