Protein-based condensation mechanisms drive the assembly of RNA-rich P granules

Protein-based condensation mechanisms drive the assembly of RNA-rich P granules

Germ granules are protein-RNA condensates that segregate with the embryonic germline. In Caenorhabditis elegans embryos, germ (P) granule assembly requires MEG-3, an intrinsically disordered protein that forms RNA-rich condensates on the surface of PGL condensates at the core of P granules. MEG-3 is...

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Bibliographic Details
Main Authors: Helen Schmidt, Andrea Putnam, Dominique Rasoloson, Geraldine Seydoux
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
RNA granule
intrinsically disordered protein
phase separation
germ plasm
P granule
Online Access:https://elifesciences.org/articles/63698

Internet

https://elifesciences.org/articles/63698

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