Enhanced GATA4 expression in senescent systemic lupus erythematosus monocytes promotes high levels of IFNα production

Enhanced GATA4 expression in senescent systemic lupus erythematosus monocytes promotes high levels of IFNα production

Enhanced interferon α (IFNα) production has been implicated in the pathogenesis of systemic lupus erythematosus (SLE). We previously reported IFNα production by monocytes upon activation of the stimulator of IFN genes (STING) pathway was enhanced in patients with SLE. We investigated the mechanism o...

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Bibliographic Details
Main Authors: Taiga Kuga, Asako Chiba, Goh Murayama, Kosuke Hosomi, Tomoya Nakagawa, Yoshiyuki Yahagi, Daisuke Noto, Makio Kusaoi, Fuminori Kawano, Ken Yamaji, Naoto Tamura, Sachiko Miyake
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
SLE
monocyte
interferon
cellular senescence
GATA4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1320444/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1320444/full

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