Design, synthesis and anticancer activity studies of 3-(coumarin-3-yl)-acrolein derivatives: Evidenced by integrating network pharmacology and vitro assay

Design, synthesis and anticancer activity studies of 3-(coumarin-3-yl)-acrolein derivatives: Evidenced by integrating network pharmacology and vitro assay

Coumarin derivatives have diverse structures and show various significant biological activities. Aiming to develop more potent coumarin derivatives for cancer treatment, a series of coumarin acrolein hybrids were designed and synthesized by using molecular hybridization approach, and investigated fo...

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Bibliographic Details
Main Authors: Lexian Chen, Qianqian Lv, Jianghong Cai, Jiajie Liang, Ziyan Liang, Jiahui Lin, Ying Xiao, Ruiyao Chen, Zhiling Zhang, Yue Hong, Hong Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
coumarin
acrolein
synthesis
antitumor activity
network pharmacology
PI3K/AKT pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1141121/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1141121/full

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