Efficacy of novel agents against cellular models of familial platelet disorder with myeloid malignancy (FPD-MM)

Efficacy of novel agents against cellular models of familial platelet disorder with myeloid malignancy (FPD-MM)

Abstract Germline, mono-allelic mutations in RUNX1 cause familial platelet disorder (RUNX1-FPD) that evolves into myeloid malignancy (FPD-MM): MDS or AML. FPD-MM commonly harbors co-mutations in the second RUNX1 allele and/or other epigenetic regulators. Here we utilized patient-derived (PD) FPD-MM...

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Bibliographic Details
Main Authors: Christopher P. Mill, Warren C. Fiskus, Courtney D. DiNardo, Patrick Reville, John A. Davis, Christine E. Birdwell, Kaberi Das, Hanxi Hou, Koichi Takahashi, Lauren Flores, Xinjia Ruan, Xiaoping Su, Sanam Loghavi, Joseph D. Khoury, Kapil N. Bhalla
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-024-00981-4

Internet

https://doi.org/10.1038/s41408-024-00981-4

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