Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5

Abstract There is an urgent need for improved malaria vaccine immunogens. Invasion of erythrocytes by Plasmodium falciparum is essential for its life cycle, preceding symptoms of disease and parasite transmission. Antibodies which target PfRH5 are highly effective at preventing erythrocyte invasion...

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Detalhes bibliográficos
Principais autores: Thomas E Harrison, Nawsad Alam, Brendan Farrell, Doris Quinkert, Amelia M Lias, Lloyd D W King, Lea K Barfod, Simon J Draper, Ivan Campeotto, Matthew K Higgins
Formato: Artigo
Idioma:English
Publicado em: Springer Nature 2024-09-01
coleção:EMBO Molecular Medicine
Assuntos:
Malaria
Vaccines
PfRH5
Monoclonal Antibodies
Rational Vaccine Immunogen Design
Acesso em linha:https://doi.org/10.1038/s44321-024-00123-0

Internet

https://doi.org/10.1038/s44321-024-00123-0

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