TARGETING THE EPIGENOME IN LUNG CANCER: EXPANDING APPROACHES TO EPIGENETIC THERAPY

TARGETING THE EPIGENOME IN LUNG CANCER: EXPANDING APPROACHES TO EPIGENETIC THERAPY

Epigenetic aberrations offer dynamic and reversible targets for cancer therapy; increasingly, alteration via overexpression, mutation, or rearrangement is found in genes that control the epigenome. Such alterations suggest a fundamental role in carcinogenesis. Here, we consider three epigenetic mec...

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Bibliographic Details
Main Authors: Marko eJakopovic, Anish eThomas, Sanjeeve eBalasubramaniam, David eSchrump, Giuseppe eGiaccone, Susan E. Bates
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Oncology
Subjects:
DNA methyltransferase inhibitors
epigenome
HDAC inhibitors
lung carcinogenesis
epigenetic therapy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00261/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00261/full

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