Dedifferentiated early postnatal lung myofibroblasts redifferentiate in adult disease

Dedifferentiated early postnatal lung myofibroblasts redifferentiate in adult disease

Alveolarization ensures sufficient lung surface area for gas exchange, and during bulk alveolarization in mice (postnatal day [P] 4.5–14.5), alpha-smooth muscle actin (SMA)+ myofibroblasts accumulate, secrete elastin, and lay down alveolar septum. Herein, we delineate the dynamics of the lineage of...

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Bibliographic Details
Main Authors: Rachana R. Chandran, Taylor S. Adams, Inamul Kabir, Eunate Gallardo-Vara, Naftali Kaminski, Brigitte N. Gomperts, Daniel M. Greif
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
lung myofibroblasts
fate mapping
alveolarization
hypoxia
pulmonary hypertension
lung fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1335061/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2024.1335061/full

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