CXCL12 promotes atherosclerosis by downregulating ABCA1 expression via the CXCR4/GSK3β/β-cateninT120/TCF21 pathway

CXCL12 promotes atherosclerosis by downregulating ABCA1 expression via the CXCR4/GSK3β/β-cateninT120/TCF21 pathway

CXC chemokine ligand 12 (CXCL12) is a member of the CXC chemokine family and mainly acts on cell chemotaxis. CXCL12 also elicits a proatherogenic role, but the molecular mechanisms have not been fully defined yet. We aimed to reveal if and how CXCL12 promoted atherosclerosis via regulating lipid met...

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Bibliographic Details
Main Authors: Jia-Hui Gao, Lin-Hao He, Xiao-Hua Yu, Zhen-Wang Zhao, Gang Wang, Jin Zou, Feng-Jiao Wen, Li Zhou, Xiang-Jun Wan, Da-Wei Zhang, Chao-Ke Tang
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Journal of Lipid Research
Subjects:
CXC chemokine ligand 12
CXC chemokine receptor 4
ATP binding cassette transporter A1
cholesterol efflux
glycogen synthase kinase 3β
transcription factor 21
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520310415

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http://www.sciencedirect.com/science/article/pii/S0022227520310415

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