Glycosylation of H4 influenza strains with pandemic potential and susceptibilities to lung surfactant SP-D

We recently reported that members of group 1 influenza A virus (IAV) containing H2, H5, H6, and H11 hemagglutinins (HAs) are resistant to lung surfactant protein D (SP-D). H3 viruses, members of group 2 IAV, have high affinity for SP-D, which depends on the presence of high-mannose glycans at glycos...

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Main Authors: Lisa M. Parsons, Olga Zoueva, Gabrielle Grubbs, Ewan Plant, Ewa Jankowska, Yijia Xie, Hao Song, George F. Gao, Zhiping Ye, Surender Khurana, John F. Cipollo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Molecular Biosciences
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Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1207670/full