Doxorubicin/Nucleophosmin Binding Protein-Conjugated Nanoparticle Enhances Anti-leukemia Activity in Acute Lymphoblastic Leukemia Cells in vitro and in vivo

Doxorubicin/Nucleophosmin Binding Protein-Conjugated Nanoparticle Enhances Anti-leukemia Activity in Acute Lymphoblastic Leukemia Cells in vitro and in vivo

Acute lymphoblastic leukemia (ALL) is an aggressive malignancy. Adults with ALL have more than 50% relapse rates. We have previously validated that overexpression of nucleophosmin (NPM) is involved in the multidrug resistance (MDR) development during ALL; and a synthetically engineered recombinant N...

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Bibliographic Details
Main Authors: Donghui Gan, Yuwen Chen, Zhengjun Wu, Liping Luo, Shimuye Kalayu Yirga, Na Zhang, Fu Ye, Haijun Chen, Jianda Hu, Yingyu Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
acute lymphoblastic leukemia
p53
apoptosis
doxorubicin (dox)
multidrug resistance (MDR)
nanoparticle
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.607755/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.607755/full

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