Infected cell killing by HIV-1 protease promotes NF-kappaB dependent HIV-1 replication.

Infected cell killing by HIV-1 protease promotes NF-kappaB dependent HIV-1 replication.

Acute HIV-1 infection of CD4 T cells often results in apoptotic death of infected cells, yet it is unclear what evolutionary advantage this offers to HIV-1. Given the independent observations that acute T cell HIV-1 infection results in (1) NF-kappaB activation, (2) caspase 8 dependent apoptosis, an...

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Bibliographic Details
Main Authors: Gary D Bren, Joe Whitman, Nathan Cummins, Brett Shepard, Stacey A Rizza, Sergey A Trushin, Andrew D Badley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2346551?pdf=render

Internet

http://europepmc.org/articles/PMC2346551?pdf=render

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