Hedgehog Suppresses Paclitaxel Sensitivity by Regulating Akt-Mediated Phosphorylation of Bax in EGFR Wild-Type Non-Small Cell Lung Cancer Cells

Hedgehog Suppresses Paclitaxel Sensitivity by Regulating Akt-Mediated Phosphorylation of Bax in EGFR Wild-Type Non-Small Cell Lung Cancer Cells

Non-small cell lung cancer (NSCLC) is one of the most common and deadly cancers worldwide. Among NSCLC patients, almost half have wild-type epidermal growth factor receptor (EGFR WT). The primary therapeutic option for these EGFR WT NSCLC patients is chemotherapy, while NSCLC patients with EGFR muta...

Full description

Bibliographic Details
Main Authors: Yun-Chieh Tu, Wei-Chen Yeh, Hsin-Hsien Yu, Yu-Cheng Lee, Bor-Chyuan Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
Hedgehog
EGFR
paclitaxel
GDC-0449
non-small cell lung cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.815308/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.815308/full

Similar Items