Hedgehog Suppresses Paclitaxel Sensitivity by Regulating Akt-Mediated Phosphorylation of Bax in EGFR Wild-Type Non-Small Cell Lung Cancer Cells

Hedgehog Suppresses Paclitaxel Sensitivity by Regulating Akt-Mediated Phosphorylation of Bax in EGFR Wild-Type Non-Small Cell Lung Cancer Cells

Non-small cell lung cancer (NSCLC) is one of the most common and deadly cancers worldwide. Among NSCLC patients, almost half have wild-type epidermal growth factor receptor (EGFR WT). The primary therapeutic option for these EGFR WT NSCLC patients is chemotherapy, while NSCLC patients with EGFR muta...

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Bibliographic Details
Main Authors: Yun-Chieh Tu, Wei-Chen Yeh, Hsin-Hsien Yu, Yu-Cheng Lee, Bor-Chyuan Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
Hedgehog
EGFR
paclitaxel
GDC-0449
non-small cell lung cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.815308/full

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