RNA binding protein: coordinated expression between the nuclear and mitochondrial genomes in tumors
Abstract Mitochondria are the only organelles regulated by two genomes. The coordinated translation of nuclear DNA (nDNA) and mitochondrial DNA (mtDNA), which together co-encode the subunits of the oxidative phosphorylation (OXPHOS) complex, is critical for determining the metabolic plasticity of tu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-023-04373-3 |
| _version_ | 1797769388214976512 |
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| author | Jiaoyan Ma Liankun Sun Weinan Gao Yang Li Delu Dong |
| author_facet | Jiaoyan Ma Liankun Sun Weinan Gao Yang Li Delu Dong |
| author_sort | Jiaoyan Ma |
| collection | DOAJ |
| description | Abstract Mitochondria are the only organelles regulated by two genomes. The coordinated translation of nuclear DNA (nDNA) and mitochondrial DNA (mtDNA), which together co-encode the subunits of the oxidative phosphorylation (OXPHOS) complex, is critical for determining the metabolic plasticity of tumor cells. RNA-binding protein (RBP) is a post-transcriptional regulatory factor that plays a pivotal role in determining the fate of mRNA. RBP rapidly and effectively reshapes the mitochondrial proteome in response to intracellular and extracellular stressors, mediating the cytoplasmic and mitochondrial translation balance to adjust mitochondrial respiratory capacity and provide energy for tumor cells to adapt to different environmental pressures and growth needs. This review highlights the ability of RBPs to use liquid–liquid phase separation (LLPS) as a platform for translation regulation, integrating nuclear–mitochondrial positive and retrograde signals to coordinate cross-department translation, reshape mitochondrial energy metabolism, and promote the development and survival of tumor cells. |
| first_indexed | 2024-03-12T21:07:20Z |
| format | Article |
| id | doaj.art-b952421ad4444045b12309e428dbde7b |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-03-12T21:07:20Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-b952421ad4444045b12309e428dbde7b2023-07-30T11:23:43ZengBMCJournal of Translational Medicine1479-58762023-07-0121111810.1186/s12967-023-04373-3RNA binding protein: coordinated expression between the nuclear and mitochondrial genomes in tumorsJiaoyan Ma0Liankun Sun1Weinan Gao2Yang Li3Delu Dong4Department of Pathophysiology, College of Basic Medical Sciences, Jilin UniversityDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin UniversityDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin UniversityDepartment of Physiology, College of Basic Medical Sciences, Jilin UniversityDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin UniversityAbstract Mitochondria are the only organelles regulated by two genomes. The coordinated translation of nuclear DNA (nDNA) and mitochondrial DNA (mtDNA), which together co-encode the subunits of the oxidative phosphorylation (OXPHOS) complex, is critical for determining the metabolic plasticity of tumor cells. RNA-binding protein (RBP) is a post-transcriptional regulatory factor that plays a pivotal role in determining the fate of mRNA. RBP rapidly and effectively reshapes the mitochondrial proteome in response to intracellular and extracellular stressors, mediating the cytoplasmic and mitochondrial translation balance to adjust mitochondrial respiratory capacity and provide energy for tumor cells to adapt to different environmental pressures and growth needs. This review highlights the ability of RBPs to use liquid–liquid phase separation (LLPS) as a platform for translation regulation, integrating nuclear–mitochondrial positive and retrograde signals to coordinate cross-department translation, reshape mitochondrial energy metabolism, and promote the development and survival of tumor cells.https://doi.org/10.1186/s12967-023-04373-3OXPHOSCytoplasmic translationMitochondrial translationRetrograde signalsLLPS |
| spellingShingle | Jiaoyan Ma Liankun Sun Weinan Gao Yang Li Delu Dong RNA binding protein: coordinated expression between the nuclear and mitochondrial genomes in tumors Journal of Translational Medicine OXPHOS Cytoplasmic translation Mitochondrial translation Retrograde signals LLPS |
| title | RNA binding protein: coordinated expression between the nuclear and mitochondrial genomes in tumors |
| title_full | RNA binding protein: coordinated expression between the nuclear and mitochondrial genomes in tumors |
| title_fullStr | RNA binding protein: coordinated expression between the nuclear and mitochondrial genomes in tumors |
| title_full_unstemmed | RNA binding protein: coordinated expression between the nuclear and mitochondrial genomes in tumors |
| title_short | RNA binding protein: coordinated expression between the nuclear and mitochondrial genomes in tumors |
| title_sort | rna binding protein coordinated expression between the nuclear and mitochondrial genomes in tumors |
| topic | OXPHOS Cytoplasmic translation Mitochondrial translation Retrograde signals LLPS |
| url | https://doi.org/10.1186/s12967-023-04373-3 |
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