Antibodies against Platelet Factor 4 and Their Associated Pathologies: From HIT/HITT to Spontaneous HIT-Like Syndrome, to COVID-19, to VITT/TTS

Antibodies against platelet factor 4 (PF4), a protein released from alpha-granules of activated platelets, may cause a number of pathophysiological conditions. The most commonly known is heparin-induced thrombocytopenia (HIT), which develops in a small proportion of people treated with the anticoagu...

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Bibliographic Details
Main Authors: Emmanuel J. Favaloro, Leonardo Pasalic, Giuseppe Lippi
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Antibodies
Subjects:
Online Access:https://www.mdpi.com/2073-4468/11/1/7