Effects of Altering Mitochondrial Antioxidant Capacity on Molecular and Phenotypic Drivers of Fibrocalcific Aortic Valve Stenosis

Effects of Altering Mitochondrial Antioxidant Capacity on Molecular and Phenotypic Drivers of Fibrocalcific Aortic Valve Stenosis

Background: While a small number of studies suggest that oxidative stress has an influential role in fibrocalcific aortic valve disease (FCAVD), the roles of specific antioxidant enzymes in progression of this disease remain poorly understood. Here, we focused on selectively altering mitochondrial-d...

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Bibliographic Details
Main Authors: Carolyn M. Roos, Bin Zhang, Michael A. Hagler, Grace C. Verzosa, Runqing Huang, Elise A. Oehler, Arman Arghami, Jordan D. Miller
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
MnSOD
mitochondria
fibrocalcific aortic valve disease
calcification
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.694881/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.694881/full

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