Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain

Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain

Abstract Background Paraoxonase 2 (PON2) and neuronal uncoupling proteins (UCP4 and UCP5) possess antioxidant, anti-apoptotic activities and minimize accumulation of reactive oxygen species in mitochondria. While age and sex are risk factors for several disorders that are linked with oxidative stres...

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Bibliographic Details
Main Authors: Sumit Jamwal, Jennifer K. Blackburn, John D. Elsworth
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Biology of Sex Differences
Subjects:
Pioglitazone
Uncoupling protein
Oxidative stress
Nonhuman primate
Striatum
Substantia nigra
Online Access:https://doi.org/10.1186/s13293-023-00551-6

Internet

https://doi.org/10.1186/s13293-023-00551-6

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