Integrative pan-cancer analysis of MEK1 aberrations and the potential clinical implications

Abstract Alterations of mitogen-activated protein kinase kinase 1 (MEK1) are commonly associated with tumorigenesis, and MEK1 is thought to be a suitable targeted therapy for various cancers. However, abnormal MEK1 alterations and their relevant clinical implications are unknown. Our research compre...

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Bibliographic Details
Main Authors: Zhiyang Zhou, Bi Peng, Juanni Li, Kewa Gao, Yuan Cai, Zhijie Xu, Yuanliang Yan
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97840-0