Heparanase Is a Putative Mediator of Endothelial Glycocalyx Damage in COVID-19 – A Proof-of-Concept Study

Heparanase Is a Putative Mediator of Endothelial Glycocalyx Damage in COVID-19 – A Proof-of-Concept Study

Coronavirus disease 2019 (COVID-19) is a systemic disease associated with injury (thinning) of the endothelial glycocalyx (eGC), a protective layer on the vascular endothelium. The aim of this translational study was to investigate the role of the eGC-degrading enzyme heparanase (HPSE), which is kno...

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Bibliographic Details
Main Authors: Carolin Christina Drost, Alexandros Rovas, Irina Osiaevi, Matthias Rauen, Johan van der Vlag, Baranca Buijsers, Rustem Salmenov, Alexander Lukasz, Hermann Pavenstädt, Wolfgang A. Linke, Philipp Kümpers
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
COVID-19
heparin
heparanase (HPSE)
videomicroscopy
endothelial glycocalyx (EG)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.916512/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.916512/full

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