Oxyphenbutazone ameliorates carfilzomib induced cardiotoxicity in rats via inhibition of oxidative free radical burst and NF-κB/IκB-α pathway

Oxyphenbutazone ameliorates carfilzomib induced cardiotoxicity in rats via inhibition of oxidative free radical burst and NF-κB/IκB-α pathway

Carfilzomib (CFZ), a chemotherapeutic agent used for multiple myeloma treatments reported to cause high incidence of cardiac events either new onset and/or exacerbate formerly diagnosed heart failure with ventricular and myocardial dysfunction.Purpose: Current research designed to explore and examin...

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Bibliographic Details
Main Authors: Faisal Imam, Muhammad Afzal, Nehmat Ghaboura, Khalid Saad Alharbi, Imran Kazmi, Samiyah Alshehri, Sana Saeed Alqarni, Emine Guven
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Saudi Pharmaceutical Journal
Subjects:
Cardiotoxicity
Carfilzomib
Oxyphenbutazone
Chemotherapy
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016423004218

Internet

http://www.sciencedirect.com/science/article/pii/S1319016423004218

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