Genetic, Phenotypic, and Clinical Heterogeneity of NPM1-Mutant Acute Myeloid Leukemias

Genetic, Phenotypic, and Clinical Heterogeneity of NPM1-Mutant Acute Myeloid Leukemias

The current classification of acute myeloid leukemia (AML) relies largely on genomic alterations. AML with mutated nucleophosmin 1 (<i>NPM1-mut</i>) is the largest of the genetically defined groups, involving about 30% of adult AMLs and is currently recognized as a distinct entity in the...

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Bibliographic Details
Main Authors: Ugo Testa, Elvira Pelosi, Germana Castelli
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Biomedicines
Subjects:
acute myeloid leukemia
genetic classification
mutational profiling
transcriptome analysis
prognostic stratification
clonal evolution
Online Access:https://www.mdpi.com/2227-9059/11/7/1805

Internet

https://www.mdpi.com/2227-9059/11/7/1805

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