In-silico guided chemical exploration of KDM4A fragments hits

In-silico guided chemical exploration of KDM4A fragments hits

Abstract Background Lysine demethylase enzymes (KDMs) are an emerging class of therapeutic targets, that catalyse the removal of methyl marks from histone lysine residues regulating chromatin structure and gene expression. KDM4A isoform plays an important role in the epigenetic dysregulation in vari...

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Bibliographic Details
Main Authors: Jessica Lombino, Rosario Vallone, Maura Cimino, Maria Rita Gulotta, Giada De Simone, Maria Agnese Morando, Raffaele Sabbatella, Simona Di Martino, Mario Fogazza, Federica Sarno, Claudia Coronnello, Maria De Rosa, Chiara Cipollina, Lucia Altucci, Ugo Perricone, Caterina Alfano
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Clinical Epigenetics
Subjects:
Epigenetic regulation
Lysine demethylases
KDM4 inhibitors
Fragment-based drug discovery (FBDD)
KDM4A
Rational drug design
Online Access:https://doi.org/10.1186/s13148-023-01613-7

Internet

https://doi.org/10.1186/s13148-023-01613-7

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