NaV1.9 Potentiates Oxidized Phospholipid-Induced TRP Responses Only under Inflammatory Conditions

NaV1.9 Potentiates Oxidized Phospholipid-Induced TRP Responses Only under Inflammatory Conditions

Oxidized phospholipids (OxPL) like oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC) were recently identified as novel proalgesic targets in acute and chronic inflammatory pain. These endogenous chemical irritants are generated in inflamed tissue and mediate their pain-inducin...

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Bibliographic Details
Main Authors: Corinna Martin, Carolin Stoffer, Milad Mohammadi, Julian Hugo, Enrico Leipold, Beatrice Oehler, Heike L. Rittner, Robert Blum
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
DRG neurons
inflammatory mediators
excitability
oxidized phospholipid
TRP ion channel
voltage-gated sodium channel
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00007/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00007/full

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