NaV1.9 Potentiates Oxidized Phospholipid-Induced TRP Responses Only under Inflammatory Conditions

NaV1.9 Potentiates Oxidized Phospholipid-Induced TRP Responses Only under Inflammatory Conditions

Oxidized phospholipids (OxPL) like oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC) were recently identified as novel proalgesic targets in acute and chronic inflammatory pain. These endogenous chemical irritants are generated in inflamed tissue and mediate their pain-inducin...

Full description

Bibliographic Details
Main Authors:	Corinna Martin, Carolin Stoffer, Milad Mohammadi, Julian Hugo, Enrico Leipold, Beatrice Oehler, Heike L. Rittner, Robert Blum
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-01-01
Series:	Frontiers in Molecular Neuroscience
Subjects:	DRG neurons inflammatory mediators excitability oxidized phospholipid TRP ion channel voltage-gated sodium channel
Online Access:	http://journal.frontiersin.org/article/10.3389/fnmol.2018.00007/full

Similar Items

Pain Control by Targeting Oxidized Phospholipids: Functions, Mechanisms, Perspectives
by: Beatrice Oehler, et al.
Published: (2021-01-01)

TRP channels /
by: Zhu, Michael X. 524478
Published: (2011)

G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons
by: Talisia Quallo, et al.
Published: (2017-08-01)

TRP Channels as Molecular Targets to Relieve Cancer Pain
by: Milena Duitama, et al.
Published: (2021-12-01)

Functional food development: Insights from TRP channels
by: Zhi-Ming Zhang, et al.
Published: (2019-05-01)

The involvement of TRP channels in bone homeostasis
by: Liesbet eLieben, et al.
Published: (2012-08-01)

Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression
by: Gonçalo Mesquita, et al.
Published: (2021-04-01)

Steroids and TRP Channels: A Close Relationship
by: Karina Angélica Méndez-Reséndiz, et al.
Published: (2020-05-01)

Schistosome TRP channels: An appraisal
by: Swarna Bais, et al.
Published: (2020-08-01)

TRP drop, TRP drop: a steady patter of anti-schistosomal target illumination
by: Daniel J. Sprague, et al.
Published: (2024-02-01)

TRP Channels in Tension-Type Headache: A Pilot Study
by: Yağmur İnalkaç Gemici, et al.
Published: (2021-12-01)

TRP channels in microglia: role in physiology and disease
by: Yolima P Torres
Published: (2015-02-01)

Transient Receptor Potential (TRP) and Thermoregulation in Animals: Structural Biology and Neurophysiological Aspects
by: Karina Lezama-García, et al.
Published: (2022-01-01)

General anaesthesia-related complications of gut motility with a focus on cholinergic mechanisms, TRP channels and visceral pain
by: Alexander V. Zholos, et al.
Published: (2023-05-01)

TRP Channels Regulation of Rho GTPases in Brain Context and Diseases
by: Boris Lavanderos, et al.
Published: (2020-11-01)

Sequence and structural conservation reveal fingerprint residues in TRP channels
by: Deny Cabezas-Bratesco, et al.
Published: (2022-06-01)

TRP Channels Expression Profile in Human End-Stage Heart Failure
by: Martin Dragún, et al.
Published: (2019-07-01)

Progress in the Structural Basis of thermoTRP Channel Polymodal Gating
by: Gregorio Fernández-Ballester, et al.
Published: (2023-01-01)

Pregnenolone Sulfate: From Steroid Metabolite to TRP Channel Ligand
by: Christian Harteneck
Published: (2013-09-01)

Renal vascular TRP channels
by: Praghalathan Kanthakumar, et al.
Published: (2021-01-01)

Ligand-Binding Sites in Vanilloid-Subtype TRP Channels
by: Maria V. Yelshanskaya, et al.
Published: (2022-05-01)

TRP channels in schistosomes
by: Swarna Bais, et al.
Published: (2016-12-01)

“ThermoTRP” Channel Expression in Cancers: Implications for Diagnosis and Prognosis (Practical Approach by a Pathologist)
by: Arpad Szallasi
Published: (2023-05-01)

Function of TRP channels in monocytes/macrophages
by: Jiangbo Wu, et al.
Published: (2023-06-01)

TRP channels associated with macrophages as targets for the treatment of obese asthma
by: Wenzhao Zhu, et al.
Published: (2024-02-01)

Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms
by: Jian Huang, et al.
Published: (2024-01-01)

Understanding the structure and interactions of polycystin-2 through structural and simulation studies
by: Wang, Q
Published: (2019)

TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases
by: Yusheng Liu, et al.
Published: (2022-04-01)

Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms
by: Katherine E Huffer, et al.
Published: (2020-08-01)

TRP Channels in Cancer: Signaling Mechanisms and Translational Approaches
by: Matilde Marini, et al.
Published: (2023-10-01)

Editorial: Involvements of TRP Channels and Oxidative Stress in Pain
by: Cristina Carrasco, et al.
Published: (2018-08-01)

Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels
by: Raiana dos Anjos Moraes, et al.
Published: (2021-02-01)

TRP Channels: Current Perspectives in the Adverse Cardiac Remodeling
by: Debora Falcón, et al.
Published: (2019-03-01)

Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts
by: Susan Huang, et al.
Published: (2017-07-01)

TRP Channels as Sensors of Aldehyde and Oxidative Stress
by: Katharina E. M. Hellenthal, et al.
Published: (2021-09-01)

New Frontiers on ER Stress Modulation: Are TRP Channels the Leading Actors?
by: Vincenzo Vestuto, et al.
Published: (2022-12-01)

Responses to transient receptor potential (TRP) channel agonists in Chlamydomonas reinhardtii
by: Mamoru Wada, et al.
Published: (2020-07-01)

TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain
by: Maite Artero-Morales, et al.
Published: (2018-08-01)

Comprehensive Analysis of TRP Channel–Related Genes in Patients With Triple-Negative Breast Cancer for Guiding Prognostic Prediction
by: Haojie Zhang, et al.
Published: (2022-07-01)

A Novel Gain-of-Function Nav1.9 Mutation in a Child With Episodic Pain
by: Jianying Huang, et al.
Published: (2019-09-01)