Characterization of Domiphen Bromide as a New Fast-Acting Antiplasmodial Agent Inhibiting the Apicoplastidic Methyl Erythritol Phosphate Pathway

Characterization of Domiphen Bromide as a New Fast-Acting Antiplasmodial Agent Inhibiting the Apicoplastidic Methyl Erythritol Phosphate Pathway

The evolution of resistance by the malaria parasite to artemisinin, the key component of the combination therapy strategies that are at the core of current antimalarial treatments, calls for the urgent identification of new fast-acting antimalarials. The apicoplast organelle is a preferred target of...

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Bibliographic Details
Main Authors: Arnau Biosca, Miriam Ramírez, Alex Gomez-Gomez, Aritz Lafuente, Valentín Iglesias, Oscar J. Pozo, Santiago Imperial, Xavier Fernàndez-Busquets
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceutics
Subjects:
malaria
<i>Plasmodium falciparum</i>
domiphen bromide
methyl erythritol phosphate pathway
antimalarial drugs
antibiotics
Online Access:https://www.mdpi.com/1999-4923/14/7/1320

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https://www.mdpi.com/1999-4923/14/7/1320

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