The Mathematics of a Successful Deconvolution: A Quantitative Assessment of Mixture-Based Combinatorial Libraries Screened Against Two Formylpeptide Receptors

The Mathematics of a Successful Deconvolution: A Quantitative Assessment of Mixture-Based Combinatorial Libraries Screened Against Two Formylpeptide Receptors

In the past 20 years, synthetic combinatorial methods have fundamentally advanced the ability to synthesize and screen large numbers of compounds for drug discovery and basic research. Mixture-based libraries and positional scanning deconvolution combine two approaches for the rapid identification o...

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Bibliographic Details
Main Authors: Richard A. Houghten, Larry A. Sklar, Bruce S. Edwards, Marc A. Giulianotti, Jon R. Appel, Radleigh G. Santos, Clemencia Pinilla
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:Molecules
Subjects:
combinatorial libraries
mixture-based libraries
harmonic mean mixture model
mathematical modeling
formylpeptide receptors
Online Access:http://www.mdpi.com/1420-3049/18/6/6408

Internet

http://www.mdpi.com/1420-3049/18/6/6408

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