Chronic Rapamycin administration via drinking water mitigates the pathological phenotype in a Krabbe disease mouse model through autophagy activation

Chronic Rapamycin administration via drinking water mitigates the pathological phenotype in a Krabbe disease mouse model through autophagy activation

Krabbe disease (KD) is a rare disorder arising from the deficiency of the lysosomal enzyme galactosylceramidase (GALC), leading to the accumulation of the cytotoxic metabolite psychosine (PSY) in the nervous system. This accumulation triggers demyelination and neurodegeneration, and despite ongoing...

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Bibliographic Details
Main Authors: Ambra Del Grosso, Sara Carpi, Miriam De Sarlo, Luca Scaccini, Laura Colagiorgio, Husam B.R. Alabed, Lucia Angella, Roberto Maria Pellegrino, Ilaria Tonazzini, Carla Emiliani, Marco Cecchini
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Krabbe disease
Globoid cell leukodystrophy
autophagy induction
Rapamycin
psychosine
Twitcher mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222400235X

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http://www.sciencedirect.com/science/article/pii/S075333222400235X

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