Alpha-Herpesvirus Thymidine Kinase Genes Mediate Viral Virulence and Are Potential Therapeutic Targets

Alpha-Herpesvirus Thymidine Kinase Genes Mediate Viral Virulence and Are Potential Therapeutic Targets

Alpha-herpesvirus thymidine kinase (TK) genes are virulence-related genes and are nonessential for viral replication; they are often preferred target genes for the construction of gene-deleted attenuated vaccines and genetically engineered vectors for inserting and expressing foreign genes. The enzy...

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Bibliographic Details
Main Authors: Ying Xie, Liping Wu, Mingshu Wang, Anchun Cheng, Qiao Yang, Ying Wu, Renyong Jia, Dekang Zhu, XinXin Zhao, Shun Chen, Mafeng Liu, Shaqiu Zhang, Yin Wang, Zhiwen Xu, Zhengli Chen, Ling Zhu, Qihui Luo, Yunya Liu, Yanling Yu, Ling Zhang, Xiaoyue Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Microbiology
Subjects:
α-Herpesvirus
thymidine kinase genes
thymidine kinases
viral virulence
latent infection
antiviral treatments
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00941/full

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00941/full

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