Age-related reduction in brain ACE-2 is not exacerbated by Alzheimer’s disease pathology in mouse models of Alzheimer’s disease

An imbalance in the circulatory and organ-specific renin-angiotensin system (RAS) pathways is associated with age-related dysfunction and disease including cardiovascular burden and more recently Alzheimer’s disease (AD). It is currently unclear whether an age-associated imbalance in components of t...

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Bibliographic Details
Main Authors: Robert MacLachlan, Charles E. Evans, Siew Yeen Chai, Mark A. Good, Patrick Gavin Kehoe, J. Scott Miners
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Aging Brain
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589958922000342