IRF3-mediated pathogenicity in a murine model of human hepatitis A.

IRF3-mediated pathogenicity in a murine model of human hepatitis A.

HAV-infected Ifnar1-/- mice recapitulate many of the cardinal features of hepatitis A in humans, including serum alanine aminotransferase (ALT) elevation, hepatocellular apoptosis, and liver inflammation. Previous studies implicate MAVS-IRF3 signaling in pathogenesis, but leave unresolved the role o...

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Bibliographic Details
Main Authors: Lu Sun, You Li, Ichiro Misumi, Olga González-López, Lucinda Hensley, John M Cullen, David R McGivern, Mami Matsuda, Ryosuke Suzuki, Ganes C Sen, Asuka Hirai-Yuki, Jason K Whitmire, Stanley M Lemon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009960

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https://doi.org/10.1371/journal.ppat.1009960

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