Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.

Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.

The intraerythrocytic parasite Plasmodium -- the causative agent of malaria -- produces an inorganic crystal called hemozoin (Hz) during the heme detoxification process, which is released into the circulation during erythrocyte lysis. Hz is rapidly ingested by phagocytes and induces the production o...

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Bibliographic Details
Main Authors: Marina Tiemi Shio, Stephanie C Eisenbarth, Myriam Savaria, Adrien F Vinet, Marie-Josée Bellemare, Kenneth W Harder, Fayyaz S Sutterwala, D Scott Bohle, Albert Descoteaux, Richard A Flavell, Martin Olivier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2722371?pdf=render

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http://europepmc.org/articles/PMC2722371?pdf=render

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