Computer-assisted stabilization of fibroblast growth factor FGF-18

Computer-assisted stabilization of fibroblast growth factor FGF-18

The fibroblast growth factors (FGF) family holds significant potential for addressing chronic diseases. Specifically, recombinant FGF18 shows promise in treating osteoarthritis by stimulating cartilage formation. However, recent phase 2 clinical trial results of sprifermin (recombinant FGF18) indica...

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Bibliographic Details
Main Authors: Jan Vilim, Tereza Ghazalova, Eliska Petulova, Aneta Horackova, Veronika Stepankova, Radka Chaloupkova, David Bednar, Jiri Damborsky, Zbynek Prokop
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Computer-assisted stabilization
Fibroblast growth factor
Thermostability
Resistance to
Protease
Improved yield
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023003665

Internet

http://www.sciencedirect.com/science/article/pii/S2001037023003665

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