Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia.

Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia.

Repeated water avoidance stress (WAS) induces sustained visceral hyperalgesia (VH) in rats measured as enhanced visceromotor response to colorectal distension (CRD). This model incorporates two characteristic features of human irritable bowel syndrome (IBS), VH and a prominent role of stress in the...

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Bibliographic Details
Main Authors: Zhuo Wang, Marco A Ocampo, Raina D Pang, Mihail Bota, Sylvie Bradesi, Emeran A Mayer, Daniel P Holschneider
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3602545?pdf=render

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http://europepmc.org/articles/PMC3602545?pdf=render

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