Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity

Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity

Abstract Background Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown. Objectives To determine (i) the expression profile of uP...

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Bibliographic Details
Main Authors: Michael A. Portelli, Sangita Bhaker, Vincent Pang, David O. Bates, Simon R. Johnson, Andrew P. Mazar, Dominick Shaw, Christopher Brightling, Ian Sayers
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Clinical and Translational Allergy
Subjects:
asthma
barrier
bronchial epithelial cells
urokinase plasminogen receptor
Online Access:https://doi.org/10.1002/clt2.12293

Internet

https://doi.org/10.1002/clt2.12293

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