Melting and Re-Freezing Leads to Irreversible Changes in the Morphology and Molecular-Level Dynamics of Pfizer-BioNTech COVID-19 Vaccine

Melting and Re-Freezing Leads to Irreversible Changes in the Morphology and Molecular-Level Dynamics of Pfizer-BioNTech COVID-19 Vaccine

<i>Background and Objectives</i>: As an mRNA-based vaccine, the Pfizer-BioNTech COVID-19 vaccine has stringent cold storage requirements to preserve functionality of the mRNA active ingredient. To this end, lipid components of the vaccine formulation play an important role in stabilizing...

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Bibliographic Details
Main Authors: Eugene Mamontov, Luke L. Daemen, Eric Novak, Matthew B. Stone
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Medicina
Subjects:
COVID-19
vaccine
thermal stability
quasielastic neutron scattering
inelastic neutron scattering
Online Access:https://www.mdpi.com/1648-9144/57/12/1343

Internet

https://www.mdpi.com/1648-9144/57/12/1343

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