Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses

Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses

Abstract The zoonotic Rift Valley fever virus (RVFV) can cause severe disease in humans and has pandemic potential, yet no approved vaccine or therapy exists. Here we describe a dual-mechanism human monoclonal antibody (mAb) combination against RVFV that is effective at minimal doses in a lethal mou...

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Bibliographic Details
Main Authors: Nathaniel S. Chapman, Ruben J. G. Hulswit, Jonna L. B. Westover, Robert Stass, Guido C. Paesen, Elad Binshtein, Joseph X. Reidy, Taylor B. Engdahl, Laura S. Handal, Alejandra Flores, Brian B. Gowen, Thomas A. Bowden, James E. Crowe
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41171-3

Internet

https://doi.org/10.1038/s41467-023-41171-3

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