Fexinidazole for Human African Trypanosomiasis, the Fruit of a Successful Public-Private Partnership

Fexinidazole for Human African Trypanosomiasis, the Fruit of a Successful Public-Private Partnership

After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of drug discovery for HAT with special emphasis on the discovery, pre-clinical development, and operational challenge...

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Bibliographic Details
Main Authors: Sonja Bernhard, Marcel Kaiser, Christian Burri, Pascal Mäser
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Diseases
Subjects:
human African trypanosomiasis
sleeping sickness
<i>Trypanosoma brucei</i>
drug discovery
nitroimidazole
product development partnership
Online Access:https://www.mdpi.com/2079-9721/10/4/90

Internet

https://www.mdpi.com/2079-9721/10/4/90

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