PAMAM dendrimers of generation 4.5 loaded with curcumin interfere with α-synuclein aggregation

PAMAM dendrimers of generation 4.5 loaded with curcumin interfere with α-synuclein aggregation

Curcumin (CUR) is a bioactive compound that has been proposed for the treatment of various neurodegenerative diseases. However, its use is limited due to its low solubility in aqueous media and chemical instability under physiological conditions. Herein, we propose a strategy to overcome these limit...

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Bibliographic Details
Main Authors: Daniela E. Igartúa, Florencia González-Lizárraga, Carolina S. Martinez, Silvia del V. Alonso, César L. Ávila, Rosana Chehín, Nadia S. Chiaramoni, M. Jimena Prieto
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:OpenNano
Subjects:
Curcumin
PAMAM dendrimers
Α-synuclein aggregation
Antioxidant activity
Parkinson´s disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2352952023000191

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http://www.sciencedirect.com/science/article/pii/S2352952023000191

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