Combination of Engineered Expression of Polysialic Acid on Transplanted Schwann Cells and in Injured Rat Spinal Cord Promotes Significant Axonal Growth and Functional Recovery

Combination of Engineered Expression of Polysialic Acid on Transplanted Schwann Cells and in Injured Rat Spinal Cord Promotes Significant Axonal Growth and Functional Recovery

Providing cellular support and modifying the glial scar around the lesion are two key strategies for promoting axonal regeneration after spinal cord injury. We showed previously that over-expressing polysialic acid (PSA) on Schwann cells (SCs) by lentiviral vector (LV)-mediated expression of polysia...

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Bibliographic Details
Main Authors: Fangyou Gao, Yi Zhang, Dongsheng Wu, Juan Luo, Svetlana Gushchina, Xuenong Bo
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Neuroglia
Subjects:
spinal cord injury
polysialic acid
Schwann cell
transplantation
corticospinal axon
axonal regeneration
Online Access:https://www.mdpi.com/2571-6980/4/4/16

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https://www.mdpi.com/2571-6980/4/4/16

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